Tau Oligomers Cause Toxicity and Impairment of Memory Formation
Oligomerix has shown that memory formation is impaired in mice when tau oligomers were applied to the region of the brain involved in short-term memory formation (hippocampal region). Similar treatment with tau monomer (tau that did not self-associate) did not have this effect. Memory-specific mechanisms involved in gene regulation were shown to be disrupted by these extracellular tau oligomers. The Company has also shown that certain oligomeric forms of tau oligomers are neurotoxic whereas tau monomer was not toxic using the same conditions.